血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性

doi:10.7523/j.issn.2095-6134.2010.1.017

中国科学院大学学报 ›› 2010, Vol. 27 ›› Issue (1): 133-137.DOI: 10.7523/j.issn.2095-6134.2010.1.017

血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性

杜明艳¹, 杜会山¹, 周桔², 丁文军²

1. 北京潞河医院神经内科,北京 101149;
2. 中国科学院研究生院生命科学学院, 北京 100049

收稿日期:2009-05-15 修回日期:2009-06-24 发布日期:2010-01-15
通讯作者: 丁文军

Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction

DU Ming-Yan¹, DU Hui-Shan¹, ZHOU Ju², DING Wen-Jun²

1. Department of Neurology, Luhe Hospital, Beijing 101149, China;
2. College of Life Sciences, Graduat University of the Chinese Academy of Sciences, Beijing 100049, China

Received:2009-05-15 Revised:2009-06-24 Published:2010-01-15

摘要/Abstract

摘要：

探讨汉族人群血管紧张素原(AGT)基因CD235Met-Thr变异与高血压合并脑梗塞发生的关系.采用突变基因分离聚合酶链反应(MS-PCR)方法检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的M235T等位基因型.BI组AGT基因T/T基因型频率和T等位基因频率(分别为0.720和0.811)显著高于C组(分别为0.516和0.700,P＜0.05)和EH组(分别为0.537和0.716,P＜0.05).结果提示,AGT基因CD235Met-Thr变异增加了汉族人群高血压合并脑梗塞发病的易感性.

关键词: 血管紧张素原基因, 突变基因分离聚合酶链反应, 高血压, 脑梗塞

Abstract:

The angiotensinogen (AGT) gene polymorphism was detected in the study of 82 cerebral infraction (BI) cases, 67 simple essential hypertension (EH) cases, and 95 normal cases (control) using mutagenically separated PCR (MS-PCR) technique. The association of the AGT gene CD235Met-Thr variant and cerebral infraction (BI) in Chinese hypertension disease is evaluated. The frequencies of T/T genotype and T allele (0.720 and 0.811) in the BI group were significantly higher than those in the control group (0.516 and 0.700, P<0.05) and the EH group (0.537 and 0.716, P<0.05), respectively. These results suggest that the AGT gene CD235Met-Thr variant is significantly associated with Chinese hypertensive patients with cerebral infraction.

Key words: angiotensinogen, MS-PCR, hypertension disease, cerebral infraction

中图分类号:

R743

杜明艳, 杜会山, 周桔, 丁文军. 血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性[J]. 中国科学院大学学报, 2010, 27(1): 133-137.

DU Ming-Yan, DU Hui-Shan, ZHOU Ju, DING Wen-Jun. Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction[J]. , 2010, 27(1): 133-137.

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血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性

Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction

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