新型水溶性AgBiS2纳米颗粒在光热、放射治疗与活体成像中的应用

doi:10.7523/j.issn.2095-6134.2019.06.005

中国科学院大学学报 ›› 2019, Vol. 36 ›› Issue (6): 752-759.DOI: 10.7523/j.issn.2095-6134.2019.06.005

新型水溶性AgBiS₂纳米颗粒在光热、放射治疗与活体成像中的应用

陈一伟, 彭爱东

中国科学院大学材料科学与光电技术学院, 北京 100049

收稿日期:2018-05-21 修回日期:2018-06-18 发布日期:2019-11-15
通讯作者: 彭爱东
基金资助:
国家自然科学基金（31571015）资助

Applications of water-soluble AgBiS₂ nanoparticles in photothermal/radiotherapy and in vivo imaging

CHEN Yiwei, PENG Aidong

College of Material Science and Opto-electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2018-05-21 Revised:2018-06-18 Published:2019-11-15

摘要/Abstract

摘要： 贵金属纳米材料与高Z元素纳米材料都是生物无机材料领域的重要研究对象，而同时包含两者的三元硫化物AgBiS₂纳米颗粒是首次被用于生物医疗领域。制备一种经PEG修饰的水溶性AgBiS₂纳米颗粒，并通过体外测试、细胞实验以及小鼠活体成像，证明该材料具有良好的光热杀伤、放疗增敏产生ROS与DNA损伤以及光声与CT成像能力。

关键词: AgBiS₂纳米材料, 光热治疗, 放射治疗, 活体成像

Abstract: Noble metal and high Z number nanomaterials are[JP+1]both popular stuff in the bioinorganic materials field, while the biomedical application of ternary sulfides AgBiS₂ nanomaterial containing the two nanomaterials is reported for the first time. We synthesized a water-soluble AgBiS₂ nanoparticle with PEG modification, and carried out a set of in vitro, intracellular, and mice imaging experiments that revealed its low cytotoxicity, photothermal lethality toward cancer cells, ability to cause DNA lesions by generating ROS under X-ray radiation which suppresses the reproduction of cancer cells, and good performance as photoacoustic and CT contrast agent.

Key words: AgBiS₂ nanoparticle, photothermal therapy, radiotherapy, in vivo imaging

中图分类号:

陈一伟, 彭爱东. 新型水溶性AgBiS₂纳米颗粒在光热、放射治疗与活体成像中的应用[J]. 中国科学院大学学报, 2019, 36(6): 752-759.

CHEN Yiwei, PENG Aidong. Applications of water-soluble AgBiS₂ nanoparticles in photothermal/radiotherapy and in vivo imaging[J]. , 2019, 36(6): 752-759.

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新型水溶性AgBiS₂纳米颗粒在光热、放射治疗与活体成像中的应用

Applications of water-soluble AgBiS₂ nanoparticles in photothermal/radiotherapy and in vivo imaging

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