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中国科学院大学学报 ›› 2003, Vol. 20 ›› Issue (1): 7-12.DOI: 10.7523/j.issn.2095-6134.2003.1.002

• 论文 • 上一篇    下一篇

人体血浆中Tb(Ⅲ)物种的计算机模拟研究

卢兴, 张海元, 王进平, 王悦, 杨魁跃, 牛春吉, 倪嘉缵   

  1. 中国科学院长春应用化学研究所稀土化学与物理开放实验室, 长春 130022
  • 收稿日期:2002-01-04 发布日期:2003-01-18
  • 作者简介:牛春吉E-mail: ldg@ns.ciac.jl.cn

Computer Simulation of Tb( Ⅲ )Speciation in Human Blood Plasma

Lu Xing, Zhang Haiyuan, Wang Jinping, Wang Yue, Yang Kuiyue, Niu Chunji, Ni Jiazuan   

  1. Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2002-01-04 Published:2003-01-18
  • Supported by:

    supported by National Natural Acience Found at ionof China(29890280;29971029)

摘要:

建立了人体血浆多相模型,研究了人体血浆体系中Tb(Ⅲ)物种的分布.结果表明,Tb(Ⅲ)的物种形式随着Tb(Ⅲ)的量浓度的变化而变化.当Tb(Ⅲ)的量浓度低于4.000×10-8mol/L时,大部分Tb(Ⅲ)物种以可溶态存在;当Tb(Ⅲ)的量浓度高于4.000×10-8mol/L而低于1.667×10-2mol/L时,沉淀物种(TbPO4和Tb2(CO3)3)成为Tb(Ⅲ)的主要物种.可溶的Tb(Ⅲ)在量浓度低于1.0×10-4mol/L时,主要与运铁蛋白键合,分布于[Tb(Tf)]中;当Tb(Ⅲ)的量浓度高于1.0×10-4mol/L时,运铁蛋白耗尽,可溶的Tb(Ⅲ)主要分布于[Tb(HSA)],[Tb2(Tf)],[Tb(Ox)]和[Tb(Cit)]等物种中.

关键词: 计算机模拟, 物种, 人体血浆, Tb(Ⅲ)

Abstract:

A multi-phase model of human blood plasma was developed and the Tb( Ⅲ) specia-tion in this system was studied. The results show that the speciation of Tb( Ⅲ ) depends onthe concentration of Tb( Ⅲ ). When the concentration of Tb( Ⅲ ) is below 4. 000 × 10-8 mol/L,most of Tb ( Ⅲ ) exists as soluble species while the concentration of Tb ( Ⅲ ) is in between4. 000× 10-8 mol/L and 1. 667 × 10-2 mol/L, precipitates (TbPO4 and Tb2 (CO3)3) are thedominant species of Tb(Ⅲ). Among soluble Tb(Ⅲ) species, Tb( Ⅲ) is mostly bound to thetransferrin to form [Tb(Tf)] when the concentration of soluble Tb(Ⅲ) is below 1.0 × 10-4mol/L. The concentration of soluble Tb(Ⅲ) reaches 1.0 × 10-4mol/L, thus available trans-ferrin is exceeded, and soluble Tb(Ⅲ) ions mainly distribute in [Tb(HSA)], [Tb2 (Tf)],[Tb(Ox)] and [Tb(Cit)] etc.

Key words: computer simulation, speciation, human blood plasma, terbium( Ⅲ)

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