收稿日期: 2003-01-20
修回日期: 2003-06-13
网络出版日期: 2004-03-19
基金资助
国家自然科学基金资助项目(29542006)
Prediction of Configuration for the Colchicine onthe Basis of the Helix Theory
Received date: 2003-01-20
Revised date: 2003-06-13
Online published: 2004-03-19
尹玉英 , 刘春蕴 . 运用螺旋理论推断秋水仙碱的构型[J]. 中国科学院大学学报, 2004 , 21(2) : 164 -167 . DOI: 10.7523/j.issn.2095-6134.2004.2.003
The colchicine is an important medicine for cancer.There are not only configurational problems of chiralcarbon atom but the problems of configuration and conformation similar to the biphenyl derivatives.The configurationand conformation between the two aromatic rings need to be determined after the configuartion of chiral carbon atomis determined.According to the helix theory proposed by the authors,the configuration and conformation between thetwo aromatic rings of colchicine can be conveniently deduced from its rotatory direction and value of rotation.
Key words： colchicine; configuration; helix theory
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