分子折叠体是一类由非共价键稳定的、采用有序构象的寡聚物或聚合物. 我们设计并合成了三类非天然的折叠体，包括：1）由疏溶剂作用驱动的并入萘环板块的寡聚乙二醇折叠体，2）由分子内氢键驱动的寡聚酰肼折叠体，3）由分子内氢键驱动的并入锌卟啉板块的寡聚苯酰胺折叠体. 定性和定量的研究揭示，在有机溶剂中这些折叠体可以作为非天然受体分子高效络合或识别结构匹配的有机分子和离子，并且氢键驱动的折叠体可以通过络合作用实现超分子体系的手性诱导或手性放大.

Foldamers are linear molecules that are driven by collective noncovalent forces to fold into a conformationally ordered state in solution or solid state. Three kinds of foldamers have been designed, synthesized and characterized, which include: 1) solvophobically-driven oligo(ethylene glycol) helical foldamers, 2) hydrogen bonded oligohydrazide foldamers and 3) hydrogen-bonded porphyrin-appended foldamers. The qualitative and quantitative investigations by NMR, UV-vis, fluorescent, and circular dichroism spectroscopy revealed that these foldamers can act as efficient receptors for discrete kinds of organic molecules and ions in different organic solvents. The supramolecular chiral induction or amplification has also been investigated for the hydrogen bonded folding systems.