收稿日期: 2010-06-07
修回日期: 2010-09-28
网络出版日期: 2011-07-15
基金资助
国家自然科学基金(30871388)资助
Identification and functional study of tumor suppressor Caliban interacting proteins
Received date: 2010-06-07
Revised date: 2010-09-28
Online published: 2011-07-15
王喆 , 张洁 , 赵宇亮 , 秘晓林 . 肿瘤抑制因子Caliban相互作用蛋白的筛选和验证[J]. 中国科学院大学学报, 2011 , 28(4) : 481 -488 . DOI: 10.7523/j.issn.2095-6134.2011.4.009
Caliban is a tumor suppressor. To understand its inherent mechanisms, we screened Caliban interacting proteins using the yeast two-hybrid system. We found four new Caliban interacting proteins, Bip2, Uba2, RpS27A, and CG7182. Moreover, over-expression of transcriptional factor Bip2 suppresses transcription of p 53. The tumor suppression function of p53 could be regulated through new mechanisms involving Bip2 and Caliban.
Key words： tumor suppressor; Caliban; yeast two hybrid; Bip2
[1] Khanna K K, Jackson S P. DNA double-strand breaks: signaling, repair and the cancer connection
[J]. Nat Genet, 2001, 27: 247-254.
[2] Bi X, Jones T, Abbasi F, et al. Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells
[J]. Oncogene, 2005, 24: 8229-8239.
[3] Carbonnelle D, Liehr T, Jacquot, C et al. Assignment of the serologically defined colon cancer antigen 1 gene (SDCCAG1) to human chromosome band 14q22 by in situ hybridization
[J]. Cytogenet Cell Genet, 1999, 86: 248-249.
[4] Scanlan M J, Chen Y T, Williamson B, et al. Characterization of human colon cancer antigens recognized by autologous antibodies
[J]. Int J Cancer, 1998, 76: 652-658.
[5] Nesslinger N J, Sahota R A, Stone B, et al. Standard treatments induce antigen-specific immune responses in prostate cancer
[J]. Clin Cancer Res, 2007, 13: 1493-1502.
[6] Carbonnelle D, Jacquot C, Lanco X, et al. Up-regulation of a novel mRNA (NY-CO-1) involved in the methyl 4-methoxy-3-(3-methyl-2-butenoyl) benzoate (VT1)-induced proliferation arrest of a non-small-cell lung carcinoma cell line (NSCLC-N6)
[J]. Int J Cancer, 2001, 92: 388-397.
[7] Bi X, Kajava A V, Jones T, et al. The carboxy terminus of Prospero regulates its subcellular localization
[J]. Mol Cell Biol, 2003; 23: 1014-1024.
[8] Davidson I. Drosophila melanogaster partial mRNA for TAFII155 protein, RNA polymerase II transcription factor TFIID subunit (BIP2 gene) . GenBank/EMBL/DDBJ sequence record, 2001.
[9] Bereczki O, Ujfaludi Z, Pardi N, et al. TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
[J]. BMC Mol Biol, 2008, 9: 57.
[10] Hughes J R, Meireles A M, Fisher K H, et al. A microtubule interactome: complexes with roles in cell cycle and mitosis
[J]. PLoS Biology, 2008, 6: e98.
[11] Donaghue C, Bates H, Cotterill S. Identification and characterisation of the Drosophila homologue of the yeast Uba2 gene
[J]. Biochimica et Biophysica Acta, 2001, 1518: 210-214.
[12] Bergink S, Jentsch S. Principles of ubiquitin and SUMO modifications in DNA repair
[J]. Nature, 2009, 458: 461-467.
[13] Lee J S, Thorgeirsson S S. Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets
[J]. Gastroenterology, 2004, 127: S51-55.
[14] Barrio R, del Arco A, Cabrera H L, et al. Structure and expression of the Drosophila ubiquitin-80-amino-acid fusion-protein gene
[J]. Biochem J, 1994, 302 ( Pt 1): 237-244.
[15] Lee H S, Simon J A, Lis J T. Structure and expression of ubiquitin genes of Drosophila melanogaster
[J]. Molecular and Cellular Biology, 1988, 8: 4727-4735.
[16] Shih H P, Hales K G, Peifer M, et al. Identification and characterization of elements of a Drosophilaubiquitin-like-protein conjugation pathway that may be involved in septin modification //Program and Abstracts 41st Annual Drosophila Research Conference. Pittsburgh, 2000: 35.
[17] Bhaskar V, Valentine S A, Courey A J. A functional interaction between dorsal and components of the smt3 conjugation machinery
[J]. Journal of Biological Chemistry, 2000, 275: 4033-4040.
[18] Gangloff Y G, Pointud J C, Thuault S, et al. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger
[J]. Mol Cell Biol, 2001, 21: 5109-5121.
[19] Hoffmann A, Chiang C M, Oelgeschlager T, et al. A histone octamer-like structure within TFIID
[J]. Nature, 1996, 380: 356-359.
[20] Kokubo T, Gong D W, Wootton J C, et al .Molecular cloning of Drosophila TFIID subunits
[J]. Nature, 1994, 367: 484-487.
[21] Xie X, Kokubo T, Cohen S L, et al. Structural similarity between TAFs and the heterotetrameric core of the histone octamer
[J]. Nature, 1996, 380: 316-322.
[22] Linder B, Newman R, Jones L K, et al. Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation
[J]. J Mol Biol, 2000, 299: 369-378.
[23] Aravind L, Landsman D. AT-hook motifs identified in a wide variety of DNA-binding proteins
[J]. Nucleic Acids Res, 1998, 26: 4413-4421.
[24] Pointud J C, Larsson J, Dastugue B, et al. The BTB/POZ domain of the regulatory proteins Bric a brac 1 (BAB1) and Bric a brac 2 (BAB2) interacts with the novel Drosophila TAF(II) factor BIP2/dTAF(II)155
[J]. Dev Biol, 2001, 237: 368-380.
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