基于数据融合的多时延基因调控网络的构建
收稿日期: 2011-02-21
修回日期: 2011-04-18
网络出版日期: 2012-03-15
基金资助
国家自然科学基金(60702035)资助
Construction of gene regulatory network with multiple time unit lag based on combination of multiple sources of biological data
Received date: 2011-02-21
Revised date: 2011-04-18
Online published: 2012-03-15
原义涛 , 孙应飞 . 基于数据融合的多时延基因调控网络的构建[J]. 中国科学院大学学报, 2012 , (2) : 246 -250 . DOI: 10.7523/j.issn.2095-6134.2012.2.015
We propose a new method (LC-DBN) of gene regulatory network (GRN) construction based on the theory of dynamic Bayesian network. In the process of GRN construction, we learn optimal regulation time unit lag for each gene and combine gene expression data with transcription factor binding location data. The construction experiments on GRN of 25 Saccharomyces Cerevisiae cell cycle data was carried out, and the results indicate that the new method enhances sensitivity by 0.72% and accuracy by 0.16% compared to Tan’s method.
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