合成了4种富电性的脱氢α-氨基酸衍生物,将缺电子催化剂Rh-3,5-CF3-(R)-BINAP用于这几种底物的不对称氢化反应中. 讨论了底物上取代基及空间位阻对对映选择性的影响.
Four electron-rich α-acetamidocinnamic acid derivatives were prepared and used as substrates in the asymmetric hydrogenation catalyzed by electron-deficient Rh-3,5-CF3-(R)-BINAP. Influence of the electronic properties of substituted groups in the substrates and their steric hindrance on the enantioselectivity of the product were discussed.
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