Fatty acid synthase (FAS), an important enzyme catalyzing the synthesis of long-chain fatty acid in vivo, has been reported to be a potential target for treatment of obesity. We found that xanthones with different functional groups and substituents have different inhibition activities on FAS, and the IC50 values range from 1.24 μmol/L to 1000 μmol/L and above. Structure-activity relationships for these compounds were then analyzed, and some structure-activity rules were established.
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