收稿日期: 2004-06-09
修回日期: 2004-08-06
网络出版日期: 2005-07-15
基金资助
国家重点基础研究发展计划 (973计划,2003CB515404);国家自然科学基金重点项目(30230130);中国科学院知识创新工程项目 (KSCX2SW20402)资助
Comparison between Acquisition and Retention of Morphine and Food-Induced Conditioned Place Preference
Received date: 2004-06-09
Revised date: 2004-08-06
Online published: 2005-07-15
李勇辉 , 郑希耕 , 鞠平 , 刘杰 , 杨晓燕 , 隋南 . 吗啡、食物诱导的条件性位置偏爱获得与保持的比较[J]. 中国科学院大学学报, 2005 , 22(4) : 467 -471 . DOI: 10.7523/j.issn.2095-6134.2005.4.011
To confirm the hypothesis that persistence of addiction is caused by reward-related memory of addictive drugs. 24 rats, in food restriction, were trained in biased condit ioned place preference procedure. Both morphine and food established condit ioned place preference at the same level after 6 sessions training. Food-induced CPP was extinct, while morphine- induced CPP was preserved after 4 retests. It is suggested acquisition of conditioned place preference produced by morphine and food is similar, however, morphine CPP is maintained longer. The inveterate reward-related memory induced by addictive drugs is a major factor for the persistence of addiction.
Key words： morphine; food; conditioned place preference; acquisition; retention
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