收稿日期: 2002-03-09
修回日期: 2002-05-15
网络出版日期: 2003-01-18
Process Improvement of m, p-Trifluoromethylbenzonitrile
Received date: 2002-03-09
Revised date: 2002-05-15
Online published: 2003-01-18
间,对三氟甲基苯腈是一种重要的医药、农药中间体.叙述了在一个反应器中利用NiCl2和P(C6H5)3,用还原性金属粉末原位还原生成的Ni((C6H5)3)3作为催化剂,将间、对氯三氟甲苯转化为相应的芳香腈,转化率分别达到87.0%和82.7%.该反应条件温和,易于控制,已经实现工业化生产.
关键词： 间三氟甲基苯腈; 对三氟甲基苯腈; 间氯三氟甲苯; 对氯三氟甲苯; 三(三苯基膦)合镍(0)
刘刚 . 间,对三氟甲基苯腈的工艺改进[J]. 中国科学院大学学报, 2003 , 20(1) : 103 -106 . DOI: 10.7523/j.issn.2095-6134.2003.1.016
m,p Trifluoromethylbenzonitrile are useful intermediates for synthesis of pharmaceuticals and agricultural chemicals.The article discloses that m, p chlorobenzotrifluoride are converted to m, p trifluoromethylbenzonitrile using Ni(P(C6H5)3)3 as catalyst which give 87.0% and 82.7% conversion respectively. The catalyst is prepared in situ from anhydrous NiCl 2 with PФ 3 in the presence of a reducing powder in a single reactor vessel. The reaction occurs under simple, mild conditions and easily to be controlled and has been carried out in a commercial scale.
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