贵金属纳米材料与高Z元素纳米材料都是生物无机材料领域的重要研究对象，而同时包含两者的三元硫化物AgBiS2纳米颗粒是首次被用于生物医疗领域。制备一种经PEG修饰的水溶性AgBiS2纳米颗粒，并通过体外测试、细胞实验以及小鼠活体成像，证明该材料具有良好的光热杀伤、放疗增敏产生ROS与DNA损伤以及光声与CT成像能力。
Noble metal and high Z number nanomaterials are[JP+1]both popular stuff in the bioinorganic materials field, while the biomedical application of ternary sulfides AgBiS2 nanomaterial containing the two nanomaterials is reported for the first time. We synthesized a water-soluble AgBiS2 nanoparticle with PEG modification, and carried out a set of in vitro, intracellular, and mice imaging experiments that revealed its low cytotoxicity, photothermal lethality toward cancer cells, ability to cause DNA lesions by generating ROS under X-ray radiation which suppresses the reproduction of cancer cells, and good performance as photoacoustic and CT contrast agent.
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