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人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种作用的计算机模拟研究(英文)

  • 张海元 ,
  • 王进平 ,
  • 卢兴 ,
  • 牛春吉 ,
  • 倪嘉缵
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  • 中国科学院长春应用化学研究所稀土化学与物理开放实验室, 长春 130022
ZHANG Hai-Yuan, male, born in Dec.1975, Doct er candidate

收稿日期: 2002-01-21

  修回日期: 2002-04-08

  网络出版日期: 2002-07-18

基金资助

supported by National Natural Science Foundation of China(29890280,29971029)

Computer Simulation for Effect of Pr(Ⅲ)on Zn(Ⅱ)Speciation in Human Interstitial Fluid

  • ZHANG Hai Yuan ,
  • WANG Jin Ping ,
  • LU Xin ,
  • g NIU Chun Ji ,
  • NI Jia Zuan
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  • Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022

Received date: 2002-01-21

  Revised date: 2002-04-08

  Online published: 2002-07-18

摘要

建立了人体细胞间液多相模型,研究了人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种的作用。结果表明,Pr(Ⅲ)能够影响Zn(Ⅱ)的物种分布。Zn(Ⅱ)主要分布于[Zn(HSA)],[Zn(IgG)]和 [Zn(Cys)2 H]中。Pr(Ⅲ)不能与Zn(Ⅱ)竞争HSA和IgG配体;但是,Pr(Ⅲ)能够与Zn(Ⅱ)竞争磷酸盐和碳酸盐配体,这会引起Zn(Ⅱ)物种的重新分布

本文引用格式

张海元 , 王进平 , 卢兴 , 牛春吉 , 倪嘉缵 . 人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种作用的计算机模拟研究(英文)[J]. 中国科学院大学学报, 2002 , 19(4) : 388 -393 . DOI: 10.7523/j.issn.2095-6134.2002.4.009

Abstract

A muti-phase model of metal ion speciation in human interstitial fluid has been const ructed and the effect of Pr(Ⅲ)on Zn(Ⅱ)speciation has also been studied.Result s show that Pr (Ⅲ)ions influence the distribution of Zn (Ⅱ)species.Zn (Ⅱ)is mainly dist ributed as [ Zn (HSA)], [ Zn(IgG)] and [ Zn(Cys)2H].Pr(Ⅲ)can not compete wi th Zn(Ⅱ)to fo rm HSA and IgG complex, w hile it can compete w ith Zn(Ⅱ)as phosphate and carbonate, causing the redist ribution of Zn(Ⅱ)species.

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