三碘苯酚乙基纤维素微球的制备

doi:10.7523/j.issn.2095-6134.2005.5.007

中国科学院大学学报 ›› 2005, Vol. 22 ›› Issue (5): 575-578.DOI: 10.7523/j.issn.2095-6134.2005.5.007

三碘苯酚乙基纤维素微球的制备

刘瑞丽¹, 姜庆军², 刘士远², 李文新¹

1. 中国科学院上海应用物理研究所, 上海 201800;
2. 第二军医大学, 上海 200433

收稿日期:2004-07-26 修回日期:2004-10-14 发布日期:2005-09-15
通讯作者: 刘瑞丽,E-mail:liuruili@sinap.ac.Cn

Development of 2,4,6-Triiodophenol Microspheres with Ethylcellulose

LIU Rui-Li¹, JIANG Qing-Jun², LIU Shi-Yuan², LI Wen-Xin¹

1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
2. Second Military Medical University, Shanghai 200433, China

Received:2004-07-26 Revised:2004-10-14 Published:2005-09-15

摘要/Abstract

摘要：

为提高造影剂的颗粒度,减少血池造影剂透过血管壁向组织间质渗出,影响血池造影剂的造影效果,采用液中干燥法制备了三碘苯酚乙基纤维素微球,研究了三碘苯酚与乙基纤维素的质量比对微球成球性、粒径以及载药量的影响,发现两者的质量比为1∶2时成球性最好,所得微球为规整的球形,微球粒径最小,平均粒径D50为3.68μm,载药量为41.4%.

关键词: 液中干燥法, 三碘苯酚, 乙基纤维素微球, 血池造影剂

Abstract:

In this paper,2,4,6-triiodophenol-ethylcellulose microsphere was developed by in2liquid drying method, in order to increase the granularity of the X2ray CT contrast agent and to prevent the blood vessel X-ray CT contrast agent from exuding through the vascular wall to the tissue. The influences of the composition ratio of 2,4,6-triiodophenol : ethylcellulose to the microspheres ’ appearance and diameter, and the entrapment of 2,4,6-triiodophenol were studied. It was found that when the composition ratio was 1∶2, the microspheres’ appearance was round, the average diameter was only 3168μm, and the entrapment of 2,4,6-triiodophenol was 4114 %.

Key words: in-liquid drying method,2,4,6-triiodophenol, ethylcellulose microsphere, blood vessel X-ray CT contrast agent

中图分类号:

刘瑞丽, 姜庆军, 刘士远, 李文新. 三碘苯酚乙基纤维素微球的制备[J]. 中国科学院大学学报, 2005, 22(5): 575-578.

LIU Rui-Li, JIANG Qing-Jun, LIU Shi-Yuan, LI Wen-Xin. Development of 2,4,6-Triiodophenol Microspheres with Ethylcellulose[J]. , 2005, 22(5): 575-578.

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三碘苯酚乙基纤维素微球的制备

Development of 2,4,6-Triiodophenol Microspheres with Ethylcellulose

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