V5dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究

doi:10.7523/j.issn.2095-6134.2013.05.007

中国科学院大学学报 ›› 2013, Vol. 30 ›› Issue (5): 613-619.DOI: 10.7523/j.issn.2095-6134.2013.05.007

V₅dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究

张伟, 陈德亮, 张芳, 刘杨, 丁文军

中国科学院大学生命科学学院, 北京 100049

收稿日期:2012-11-02 修回日期:2012-11-13 发布日期:2013-09-15
基金资助:
国家自然科学基金(11075207)资助 

Effect of vanadium(V)-chlorodipicolinate on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice

ZHANG Wei, CHEN De-Liang, ZHANG Fang, LIU Yang, DING Wen-Jun

College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-11-02 Revised:2012-11-13 Published:2013-09-15
Contact: 张芳,E-mail:zhangfang@ucas.ac.cn;丁文军,E-mail:dingwj@ucas.ac.cn

摘要/Abstract

摘要： 主要探讨有机钒化合物V₅dipic-Cl对高脂饲料诱导的Ⅱ-型糖尿病C57BL/6J小鼠脂代谢的影响. 结果表明,与糖尿病组相比,在给予V₅dipic-Cl(5 mg/(kg·d))28 d后,小鼠的体重、血糖和白色脂肪组织显著降低;同时,V₅dipic-Cl处理明显上调糖尿病小鼠肝中与脂肪酸氧化相关CPT1、ACO和FATP基因的mRNA表达水平. 以上结果表明,V₅dipic-Cl可以通过调控脂肪酸氧化相关基因的表达,改善糖尿病小鼠的脂代谢紊乱.

关键词: V₅dipic-Cl, Ⅱ-型糖尿病, 脂代谢紊乱, C57BL/6J, 脂肪酸氧化

Abstract: The insulin-mimic effect of vanadium compounds has been reported in both type Ⅰ and Ⅱ diabetic animal models, but the effect of vanadium compounds on lipid metabolism remains to be fully understood. We investigate the effect of V₅dipic-Cl on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice. V₅dipic-Cl was administered daily to the mice for 28 days at dose of 5 mg/(kg·d) by oral gavages. It was found that the blood glucose level and serum TG were significantly reduced after treatment with V₅dipic-Cl. It is suggested that V₅dipic-Cl improves the lipid metabolism by promoting fatty acid oxidation in liver.

Key words: V₅dipic-Cl, type Ⅱ diabetes, metabolic disorder, C57BL/6J, fatty acid oxidation

中图分类号:

Q591.5

张伟, 陈德亮, 张芳, 刘杨, 丁文军. V₅dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究[J]. 中国科学院大学学报, 2013, 30(5): 613-619.

ZHANG Wei, CHEN De-Liang, ZHANG Fang, LIU Yang, DING Wen-Jun. Effect of vanadium(V)-chlorodipicolinate on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice[J]. , 2013, 30(5): 613-619.

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V₅dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究

Effect of vanadium(V)-chlorodipicolinate on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice

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