抗乙肝病毒药物对慢性乙肝育龄患者精子质量的影响

doi:10.7523/j.issn.2095-6134.2014.04.003

中国科学院大学学报 ›› 2014, Vol. 31 ›› Issue (4): 460-465.DOI: 10.7523/j.issn.2095-6134.2014.04.003

抗乙肝病毒药物对慢性乙肝育龄患者精子质量的影响

宋丹¹, 李凌伟¹, 田菁燕¹, 甘菲菲¹, 王箭¹, 韩睿², 张芳²

1. 深圳市罗湖人民医院生殖医学中心, 广东深圳 518001;
2. 中国科学院大学生命科学学院, 北京 100049

收稿日期:2013-08-16 修回日期:2013-10-25 发布日期:2014-07-15
通讯作者: 张芳，E-mail：zhangfang@ucas.ac.cn
基金资助:
国家自然科学基金（11075207）和深圳市科技局科技计划项目（201003431）资助

Effects of anti-hepatitis B virus drugs on sperm quality of patients with chronic hepatitis B

SONG Dan¹, LI Lingwei¹, TIAN Jingyan¹, GAN Feifei¹, WANG Jian¹, HAN Rui², ZHANG Fang²

1. Reproductive Medicine Center, Shenzhen Luohu People's Hospital, Shenzhen 518001,Guangdong, China;
2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2013-08-16 Revised:2013-10-25 Published:2014-07-15

摘要/Abstract

摘要：

比较研究抗乙肝病毒药物干扰素、拉米夫定和阿德福韦酯对育龄慢性乙肝男性患者精子质量的影响.将90名20~45岁男性育龄慢性乙肝患者，随机分为干扰素治疗组、拉米夫定治疗组和阿德福韦酯治疗组.分别检测各药物组患者治疗前、治疗中和治疗后的血清HBsAg阴转率、HBeAg阴转率、抗-HBe阴转率、乙肝病毒-DNA（HBV-DNA）和谷丙转氨酶（ALT）以及精子的密度和活力.结果发现，干扰素、拉夫米定、阿德福韦酯治疗慢性乙肝的疗效显著，但治疗期间和停药3个月后，各组患者的精子密度和活力水平均显著下降（P<0.05；P<0.01），停药6个月后恢复至治疗前的水平.结果提示，干扰素、拉夫米定、阿德福韦酯均明显降低男性患者精子密度和活力的水平，影响到患者的生育力；停药后，该副作用有所缓解.

关键词: 慢性乙肝, 干扰素, 拉米夫定, 阿德福韦酯, 精子质量

Abstract:

The aim of this study was to investigate the effects of interferon, lamivudine, and adefovir on sperm quality in patients with chronic hepatitis B. A total of 90 patients with HBeAg-positive chronic hepatitis B were randomly divided into interferon-treated group, lamivudine-treated group, and adefovir-treated group. HBsAg, HBeAg, and Anti-HBe serum conversion rates, serum HBV-DNA, and alanine aminotransferase (ALT) levels in serum were measured. In addition the density and motility of sperm in these patients were also measured 6 months ofter drug with drawal. The results show that the density and motility of sperm significantly decreased in all the groups (P<0.05;P<0.01). This impairment on sperm quality was improved 6 months after drug withdrawal. The results suggest that the adverse effects of anti-hepatitis B drugs on sperm quality in chronic hepatitis B patients at reproductive age should be considered.

Key words: chronic hepatitis B, interferon, lamivudine, adefovir, sperm quality

中图分类号:

R512.6

宋丹, 李凌伟, 田菁燕, 甘菲菲, 王箭, 韩睿, 张芳. 抗乙肝病毒药物对慢性乙肝育龄患者精子质量的影响[J]. 中国科学院大学学报, 2014, 31(4): 460-465.

SONG Dan, LI Lingwei, TIAN Jingyan, GAN Feifei, WANG Jian, HAN Rui, ZHANG Fang. Effects of anti-hepatitis B virus drugs on sperm quality of patients with chronic hepatitis B[J]. , 2014, 31(4): 460-465.

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抗乙肝病毒药物对慢性乙肝育龄患者精子质量的影响

Effects of anti-hepatitis B virus drugs on sperm quality of patients with chronic hepatitis B

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