中药寒热相关药性和抑制脂肪酸合酶能力关系的探索

doi:10.7523/j.issn.2095-6134.2012.5.018

中国科学院大学学报 ›› 2012, Vol. 29 ›› Issue (5): 699-706.DOI: 10.7523/j.issn.2095-6134.2012.5.018

中药寒热相关药性和抑制脂肪酸合酶能力关系的探索

马晓丰, 刘杨, 张三国, 陈传楚, 田维熙

中国科学院研究生院, 北京 100049

收稿日期:2011-03-18 修回日期:2011-05-20 发布日期:2012-09-15
通讯作者: 田维熙
基金资助:
中国科学院研究生院院长基金(095101PY00)和王宽诚教育基金资助

Relationship between pharmic character of warm/cold traditional Chinese medicines and their inhibition to fatty acid synthase

MA Xiao-Feng, LIU Yang, ZHANG San-Guo, CHEN Chuan-Chu, TIAN Wei-Xi

Graduate University, Chinese Academy of Sciences, Beijing 100049, China

Received:2011-03-18 Revised:2011-05-20 Published:2012-09-15

摘要/Abstract

摘要： 测定了药典中106味温热性中药和119味寒凉性中药对脂肪酸合酶的抑制水平,发现温热药中对该酶强抑制的频数高于寒凉药约38%. 进一步分析发现,温热药中的温里和散内寒药中强抑制药的频数大幅提高,而寒凉药中的清热泻火、明目、清虚热药中强抑制药的频数则进一步降低,差异均具有显著性. 综合以上结果提出,直接影响能量代谢系统、造成能量代谢率变化是形成中药的寒热药性的因素之一.

关键词: 中药, 寒热药性, 脂肪酸合酶, 温里, 散寒, 清热

Abstract: We screened the inhibition ability to FAS(fatty acid synthase) for 106 warm and 119 cold TCMs(traditional Chinese medicines) in the Chinese Pharmacopiea. It is found that the frequency of strong inhibition to FAS in warming interior medicines and dissipating interior cold medicines is very high, and that in fire purging, deficiency heat purging, and heat purging-vision improving medicines is very low. The direct effect on the energy metabolism system may be a factor in formation of the warm or cold character of TCM.

Key words: traditional Chinese medicine, pharmic character of warm/cold, fatty acid synthase(FAS), warming interior, dissipating cold, heat purging

中图分类号:

R285.5

马晓丰, 刘杨, 张三国, 陈传楚, 田维熙. 中药寒热相关药性和抑制脂肪酸合酶能力关系的探索[J]. 中国科学院大学学报, 2012, 29(5): 699-706.

MA Xiao-Feng, LIU Yang, ZHANG San-Guo, CHEN Chuan-Chu, TIAN Wei-Xi. Relationship between pharmic character of warm/cold traditional Chinese medicines and their inhibition to fatty acid synthase[J]. , 2012, 29(5): 699-706.

参考文献

[1] Wang J M. Pharmacology of Chinese materia medica[M]. Shanghai Science & Technology Press, 1985: 5.
[2] Liang Y H, Wang J, Xie Z F. The effects of the cold and heat property Chinese herbs on sympathetic adrenal system and metabolization function[J]. Journal of Peking University:Health Sciences, 1987, 19(1): 54-56 (in Chinese). 梁月华,王晶,谢竹藩. 寒凉药与温热药对交感神经肾上腺及代谢机能的影响[J].北京大学学报:医学版,1987,19(1): 54-56.
[3] Smith S. The animal fatty acid synthase: one gene, one polypeptide, seven enzymes[J]. Faseb J, 1994, 8(15): 1248-1259.
[4] Loftus T M, Jaworsky D E, Frehywot G L, et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors[J]. Science, 2000, 288(5475): 2379-2381.
[5] Soukas A, Cohen P, Socci N D, et al. Leptin-specific patterns of gene expression in white sdipose tissue[J]. Genes Dev, 2000,14(8): 963-980.
[6] Li M, Shi Y, Tian W X. Factors influencing the level of fatty acid synthase complex activity in fowl[J]. Biochem Mole Biol Int, 1999, 47, 1: 63-69.
[7] Schmid B, Rippmann J F, Tadayyon M, et al. Inhibition of fatty acid synthase prevents preadipocyte differentiation[J]. Biochem Biophys Res Commun, 2005, 328(4): 1073-1082.
[8] Tzameli I, Fang H, Ollero M, et al. Regulated production of a peroxisome proliferator-acinated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes[J]. J Biol Chem, 2004, 279(34): 36093-36102.
[9] Umek R M, Fridman A D, McKnight S L. CCAAT-enhancer binding orotein: a component of a differentiation switch[J]. Science, 1991, 251(4991): 288-292.
[10] Rosen E D, Hsu C H, Wang X, et al. C/EBP alpha induces adipogenesis through PPAR gamma: a unifield pathway[J]. Genes Dev, 2002, 16(1):22-26.
[11] Menendez J A, Vazquez-Martin A, Ortega F J, et al. Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer[J]. Clin Chem, 2009, 55(3): 425-438.
[12] 国家药典委员会. 中华人民共和国药典:1部[M].2010年版. 北京:中国医药科技出版社, 2010:3-362.
[13] Soulié J M, Sheplock G J, Tian W X, et al. Hsu transient kinetic studies of fatty acid synthetase[J]. J Biol Chem, 1984, 259(1): 134-140.
[14] Tian W X, Hsu R Y, Wang Y S. Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver[J]. J Bio Chem, 1985, 260(20): 11375-11387.
[15] 黄兆胜. 中药学[M].21世纪课程教材.全国高等中医药院校教材. 北京:人民卫生出版社,2002.

中药寒热相关药性和抑制脂肪酸合酶能力关系的探索

Relationship between pharmic character of warm/cold traditional Chinese medicines and their inhibition to fatty acid synthase

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 5

编辑推荐

Metrics

本文评价

访问统计

联系我们

[1]	权小芳, 马晓丰. 氧杂蒽酮对脂肪酸合酶的抑制作用及构效分析[J]. 中国科学院大学学报, 2012, (6): 841-846.
[2]	刘晓鑫, 田维熙, 马晓丰. 草莓提取物对脂肪酸合酶及脂肪细胞的抑制作用[J]. 中国科学院大学学报, 2010, 27(6): 768-777.
[3]	孙颖慧张睿张淑妍马晓丰吴晓东田维熙. 首乌藤提取物对动物脂肪酸合酶的抑制及其减肥抑食作用 [J]. 中国科学院大学学报, 2007, 24(4): 453-459.
[4]	姜波田维熙齐桂年. 四川边茶提取物对脂肪酸合酶的抑制作用[J]. 中国科学院大学学报, 2007, 24(3): 291-299.
[5]	杜亚涛, 赵熲, 吴晓东, 田维熙. 红茶萃取物及茶黄素对两类酮酰还原酶的抑制作用[J]. 中国科学院大学学报, 2005, 22(6): 701-706.