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中国科学院大学学报 ›› 2002, Vol. 19 ›› Issue (4): 388-393.DOI: 10.7523/j.issn.2095-6134.2002.4.009

• 论文 • 上一篇    下一篇

人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种作用的计算机模拟研究(英文)

张海元1, 王进平1, 卢兴1, 牛春吉1, 倪嘉缵1   

  1. 中国科学院长春应用化学研究所稀土化学与物理开放实验室, 长春 130022
  • 收稿日期:2002-01-21 修回日期:2002-04-08 发布日期:2002-07-18
  • 作者简介:ZHANG Hai-Yuan, male, born in Dec.1975, Doct er candidate
  • 基金资助:

    supported by National Natural Science Foundation of China(29890280,29971029)

Computer Simulation for Effect of Pr(Ⅲ)on Zn(Ⅱ)Speciation in Human Interstitial Fluid

ZHANG Hai Yuan1, WANG Jin Ping1, LU Xin1, g NIU Chun Ji1, NI Jia Zuan1   

  1. Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022
  • Received:2002-01-21 Revised:2002-04-08 Published:2002-07-18

摘要:

建立了人体细胞间液多相模型,研究了人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种的作用。结果表明,Pr(Ⅲ)能够影响Zn(Ⅱ)的物种分布。Zn(Ⅱ)主要分布于[Zn(HSA)],[Zn(IgG)]和 [Zn(Cys)2 H]中。Pr(Ⅲ)不能与Zn(Ⅱ)竞争HSA和IgG配体;但是,Pr(Ⅲ)能够与Zn(Ⅱ)竞争磷酸盐和碳酸盐配体,这会引起Zn(Ⅱ)物种的重新分布

关键词: 计算机模拟, 作用, 物种, 人体细胞间液

Abstract:

A muti-phase model of metal ion speciation in human interstitial fluid has been const ructed and the effect of Pr(Ⅲ)on Zn(Ⅱ)speciation has also been studied.Result s show that Pr (Ⅲ)ions influence the distribution of Zn (Ⅱ)species.Zn (Ⅱ)is mainly dist ributed as [ Zn (HSA)], [ Zn(IgG)] and [ Zn(Cys)2H].Pr(Ⅲ)can not compete wi th Zn(Ⅱ)to fo rm HSA and IgG complex, w hile it can compete w ith Zn(Ⅱ)as phosphate and carbonate, causing the redist ribution of Zn(Ⅱ)species.

Key words: computer simulation, effect, speciation, human interstitial fluid

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