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V5dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究

  • 张伟 ,
  • 陈德亮 ,
  • 张芳 ,
  • 刘杨 ,
  • 丁文军
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  • 中国科学院大学生命科学学院, 北京 100049

收稿日期: 2012-11-02

  修回日期: 2012-11-13

  网络出版日期: 2013-09-15

基金资助

国家自然科学基金(11075207)资助 

Effect of vanadium(V)-chlorodipicolinate on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice

  • ZHANG Wei ,
  • CHEN De-Liang ,
  • ZHANG Fang ,
  • LIU Yang ,
  • DING Wen-Jun
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  • College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Received date: 2012-11-02

  Revised date: 2012-11-13

  Online published: 2013-09-15

摘要

主要探讨有机钒化合物V5dipic-Cl对高脂饲料诱导的Ⅱ-型糖尿病C57BL/6J小鼠脂代谢的影响. 结果表明,与糖尿病组相比,在给予V5dipic-Cl(5 mg/(kg·d))28 d后,小鼠的体重、血糖和白色脂肪组织显著降低;同时,V5dipic-Cl处理明显上调糖尿病小鼠肝中与脂肪酸氧化相关CPT1、ACOFATP基因的mRNA表达水平. 以上结果表明,V5dipic-Cl可以通过调控脂肪酸氧化相关基因的表达,改善糖尿病小鼠的脂代谢紊乱.

本文引用格式

张伟 , 陈德亮 , 张芳 , 刘杨 , 丁文军 . V5dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究[J]. 中国科学院大学学报, 2013 , 30(5) : 613 -619 . DOI: 10.7523/j.issn.2095-6134.2013.05.007

Abstract

The insulin-mimic effect of vanadium compounds has been reported in both type Ⅰ and Ⅱ diabetic animal models, but the effect of vanadium compounds on lipid metabolism remains to be fully understood. We investigate the effect of V5dipic-Cl on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice. V5dipic-Cl was administered daily to the mice for 28 days at dose of 5 mg/(kg·d) by oral gavages. It was found that the blood glucose level and serum TG were significantly reduced after treatment with V5dipic-Cl. It is suggested that V5dipic-Cl improves the lipid metabolism by promoting fatty acid oxidation in liver.

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