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三碘苯酚乙基纤维素微球的制备

  • 刘瑞丽 ,
  • 姜庆军 ,
  • 刘士远 ,
  • 李文新
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  • 1. 中国科学院上海应用物理研究所, 上海 201800;
    2. 第二军医大学, 上海 200433

收稿日期: 2004-07-26

  修回日期: 2004-10-14

  网络出版日期: 2005-09-15

Development of 2,4,6-Triiodophenol Microspheres with Ethylcellulose

  • LIU Rui-Li ,
  • JIANG Qing-Jun ,
  • LIU Shi-Yuan ,
  • LI Wen-Xin
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  • 1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
    2. Second Military Medical University, Shanghai 200433, China

Received date: 2004-07-26

  Revised date: 2004-10-14

  Online published: 2005-09-15

摘要

为提高造影剂的颗粒度,减少血池造影剂透过血管壁向组织间质渗出,影响血池造影剂的造影效果,采用液中干燥法制备了三碘苯酚乙基纤维素微球,研究了三碘苯酚与乙基纤维素的质量比对微球成球性、粒径以及载药量的影响,发现两者的质量比为1∶2时成球性最好,所得微球为规整的球形,微球粒径最小,平均粒径D50为3.68μm,载药量为41.4%.

本文引用格式

刘瑞丽 , 姜庆军 , 刘士远 , 李文新 . 三碘苯酚乙基纤维素微球的制备[J]. 中国科学院大学学报, 2005 , 22(5) : 575 -578 . DOI: 10.7523/j.issn.2095-6134.2005.5.007

Abstract

In this paper,2,4,6-triiodophenol-ethylcellulose microsphere was developed by in2liquid drying method, in order to increase the granularity of the X2ray CT contrast agent and to prevent the blood vessel X-ray CT contrast agent from exuding through the vascular wall to the tissue. The influences of the composition ratio of 2,4,6-triiodophenol : ethylcellulose to the microspheres ’ appearance and diameter, and the entrapment of 2,4,6-triiodophenol were studied. It was found that when the composition ratio was 1∶2, the microspheres’ appearance was round, the average diameter was only 3168μm, and the entrapment of 2,4,6-triiodophenol was 4114 %.

参考文献

[1] He GX,Wang YX.The Pharmacology and Clinical Application of Contrast Agents.Shanghai :Shanghai Science and Technology Press,2002.123 (inChinese)

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[4] Lu B.New Medicament and New Technology of Pharmaceuticals.Beijing : People’s Sanitation Press,2001.186 (in Chinese)

[5] Fan TY,Zhou XL,Wei SL.Development and evaluation of rifampin microspheres with ehylcellulose.Journal of Beijing Medical University.1999,31 (2) :28~30 (in Chinese with English abstract)

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