Performance of doxorubicin-loaded hyperbranched polyglycerol nanoparticles

doi:10.7523/j.issn.2095-6134.2018.04.009

Abstract

Abstract: Hyperbranched polyglycerol (HPG) with the molecular weight of 5 000 was synthesized from the glycide monomer via anionic polymerization. HPG nanoparticles loaded with different amounts of doxorubicin (DOX) were evaluated by fluorescence and scanning electron microscope. The results showed that HPG had good loading ability for DOX. The drug loading capacity reaches 7.25%. The doxorubicin-loaded HPG nanoparticle also showed slow-releasing and target-releasing behavior. The sustained release was kept on over 20 h. All these properties of HPG nanoparticle suggest its promising potential as an effective controlled anticancer drug-delivery system.

Key words: hyperbranched polyglycerol (HPG), drug delivery, doxorubicin(DOX), loading and releasing, nanoparticles

CLC Number:

O657

FA Mengmei, LIU Xu, WANG Ailian, ZHANG Liaoyun, YAO Xin. Performance of doxorubicin-loaded hyperbranched polyglycerol nanoparticles[J]. , 2018, 35(4): 481-486.

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