study of human-earth system is the most important content in geography; regional sustainable development relies on the reasonable structure optimal model and effective regulation of regional human-earth system. County region is a complex and opening human-earth system, taking Huangling county as an example, the environment, resources exploitation, economic development and structure evolvement of industry were systematically analyzed. And the systematical dynamic model was established and multi-projects were simulated with the theory and method of system dynamic. Optimized regulation models of human-earth system evolvement were educed based on three projects: (1) Traditional evolvement method. The intensity of resource exploitation and environment pollution is the least, but the speed of its economy development is the lowest, which restrict social sustainable development and economic reproduction. (2) Economy development method. The intensity of resource exploitation and environment pollution is the worst, economic development mostly depends on higher investment and pollution, which is a traditional mode of unsustainable development. (3) Harmonious development mode. The mode considers not only economic sustainable development and natural recourses utilizing reasonably, but also gives more attention to environment protection and harmonious development of industry, agriculture, tourism and so on. It is the optimized mode of the human-earth system evolvement.