Studies of the Radiation Induced Bystander Effects on Hprt and CD59 Genes of Human-hamster Hybrid AL Cells

ZHANG Lei-Lei; WU Li-Jun; HAN Wei; CHEN Shao-Peng; BAO Ling-Zhi; ZHAO Ye; YU Zeng-Liang

doi:10.7523/j.issn.2095-6134.2006.6.005

Journal of University of Chinese Academy of Sciences >

2006 , Vol. 23 >Issue 6: 752 - 758

DOI: https://doi.org/10.7523/j.issn.2095-6134.2006.6.005

Studies of the Radiation Induced Bystander Effects on Hprt and CD59 Genes of Human-hamster Hybrid AL Cells

ZHANG Lei-Lei ,
WU Li-Jun ,
HAN Wei ,
CHEN Shao-Peng ,
BAO Ling-Zhi ,
ZHAO Ye ,
YU Zeng-Liang

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Key Laboratory of Ion Beam Bioengineering of Chinese Academy of Scie+nces,
Institute of Plasma Physics, Hefei 230031,China

Received date: 1900-01-01

Revised date: 1900-01-01

Online published: 2006-11-15

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Abstract

To investigate signal transduction between irradiated cells and unirradiated cells and its potential mechanism, unirradiated hprt+ AL cells were co-cultured with irradiated hprt- AL cells which were then killed by HAT selected medium. Results show that irradiated hprt- AL cells could transmit damage signals to unirradiated hprt+ AL cells and increase the mutation fraction at the CD59 locus. Free radical scavenger DMSO and intercellular communication inhibitor Lindane significantly increase the survival of unirradiated cells while only Lindane treatment is able to suppress the CD59 mutagenicity in unirradiated cells. These results indicate that GJIC plays an important role in the process of RIBE.

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ZHANG Lei-Lei , WU Li-Jun , HAN Wei , CHEN Shao-Peng , BAO Ling-Zhi , ZHAO Ye , YU Zeng-Liang . Studies of the Radiation Induced Bystander Effects on Hprt and CD59 Genes of Human-hamster Hybrid AL Cells[J]. Journal of University of Chinese Academy of Sciences, 2006 , 23(6) : 752 -758 . DOI: 10.7523/j.issn.2095-6134.2006.6.005

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