We screened the inhibition ability to FAS(fatty acid synthase) for 106 warm and 119 cold TCMs(traditional Chinese medicines) in the Chinese Pharmacopiea. It is found that the frequency of strong inhibition to FAS in warming interior medicines and dissipating interior cold medicines is very high, and that in fire purging, deficiency heat purging, and heat purging-vision improving medicines is very low. The direct effect on the energy metabolism system may be a factor in formation of the warm or cold character of TCM.
MA Xiao-Feng
,
LIU Yang
,
ZHANG San-Guo
,
CHEN Chuan-Chu
,
TIAN Wei-Xi
. Relationship between pharmic character of warm/cold traditional Chinese medicines and their inhibition to fatty acid synthase[J]. Journal of University of Chinese Academy of Sciences, 2012
, 29(5)
: 699
-706
.
DOI: 10.7523/j.issn.2095-6134.2012.5.018
[1] Wang J M. Pharmacology of Chinese materia medica[M]. Shanghai Science & Technology Press, 1985: 5.
[2] Liang Y H, Wang J, Xie Z F. The effects of the cold and heat property Chinese herbs on sympathetic adrenal system and metabolization function[J]. Journal of Peking University:Health Sciences, 1987, 19(1): 54-56 (in Chinese). 梁月华,王晶,谢竹藩. 寒凉药与温热药对交感神经肾上腺及代谢机能的影响[J].北京大学学报:医学版,1987,19(1): 54-56.
[3] Smith S. The animal fatty acid synthase: one gene, one polypeptide, seven enzymes[J]. Faseb J, 1994, 8(15): 1248-1259.
[4] Loftus T M, Jaworsky D E, Frehywot G L, et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors[J]. Science, 2000, 288(5475): 2379-2381.
[5] Soukas A, Cohen P, Socci N D, et al. Leptin-specific patterns of gene expression in white sdipose tissue[J]. Genes Dev, 2000,14(8): 963-980.
[6] Li M, Shi Y, Tian W X. Factors influencing the level of fatty acid synthase complex activity in fowl[J]. Biochem Mole Biol Int, 1999, 47, 1: 63-69.
[7] Schmid B, Rippmann J F, Tadayyon M, et al. Inhibition of fatty acid synthase prevents preadipocyte differentiation[J]. Biochem Biophys Res Commun, 2005, 328(4): 1073-1082.
[8] Tzameli I, Fang H, Ollero M, et al. Regulated production of a peroxisome proliferator-acinated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes[J]. J Biol Chem, 2004, 279(34): 36093-36102.
[9] Umek R M, Fridman A D, McKnight S L. CCAAT-enhancer binding orotein: a component of a differentiation switch[J]. Science, 1991, 251(4991): 288-292.
[10] Rosen E D, Hsu C H, Wang X, et al. C/EBP alpha induces adipogenesis through PPAR gamma: a unifield pathway[J]. Genes Dev, 2002, 16(1):22-26.
[11] Menendez J A, Vazquez-Martin A, Ortega F J, et al. Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer[J]. Clin Chem, 2009, 55(3): 425-438.
[12] 国家药典委员会. 中华人民共和国药典:1部[M].2010年版. 北京:中国医药科技出版社, 2010:3-362.
[13] Soulié J M, Sheplock G J, Tian W X, et al. Hsu transient kinetic studies of fatty acid synthetase[J]. J Biol Chem, 1984, 259(1): 134-140.
[14] Tian W X, Hsu R Y, Wang Y S. Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver[J]. J Bio Chem, 1985, 260(20): 11375-11387.
[15] 黄兆胜. 中药学[M].21世纪课程教材.全国高等中医药院校教材. 北京:人民卫生出版社,2002.
