Journal of University of Chinese Academy of Sciences >
Comparison between Acquisition and Retention of Morphine and Food-Induced Conditioned Place Preference
Received date: 2004-06-09
Revised date: 2004-08-06
Online published: 2005-07-15
To confirm the hypothesis that persistence of addiction is caused by reward-related memory of addictive drugs. 24 rats, in food restriction, were trained in biased condit ioned place preference procedure. Both morphine and food established condit ioned place preference at the same level after 6 sessions training. Food-induced CPP was extinct, while morphine- induced CPP was preserved after 4 retests. It is suggested acquisition of conditioned place preference produced by morphine and food is similar, however, morphine CPP is maintained longer. The inveterate reward-related memory induced by addictive drugs is a major factor for the persistence of addiction.
Key words： morphine; food; conditioned place preference; acquisition; retention
LI Yong-Hui , ZHENG Xi-Geng , JU Ping , LIU Jie , YANG Xiao-Yan , SUI Nan . Comparison between Acquisition and Retention of Morphine and Food-Induced Conditioned Place Preference[J]. Journal of University of Chinese Academy of Sciences, 2005 , 22(4) : 467 -471 . DOI: 10.7523/j.issn.2095-6134.2005.4.011
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