Journal of University of Chinese Academy of Sciences >
Process Improvement of m, p-Trifluoromethylbenzonitrile
Received date: 2002-03-09
Revised date: 2002-05-15
Online published: 2003-01-18
m,p Trifluoromethylbenzonitrile are useful intermediates for synthesis of pharmaceuticals and agricultural chemicals.The article discloses that m, p chlorobenzotrifluoride are converted to m, p trifluoromethylbenzonitrile using Ni(P(C6H5)3)3 as catalyst which give 87.0% and 82.7% conversion respectively. The catalyst is prepared in situ from anhydrous NiCl 2 with PФ 3 in the presence of a reducing powder in a single reactor vessel. The reaction occurs under simple, mild conditions and easily to be controlled and has been carried out in a commercial scale.
Liu Gang . Process Improvement of m, p-Trifluoromethylbenzonitrile[J]. Journal of University of Chinese Academy of Sciences, 2003 , 20(1) : 103 -106 . DOI: 10.7523/j.issn.2095-6134.2003.1.016
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