超支化聚缩水甘油醚负载盐酸阿霉素纳米粒子的性能

doi:10.7523/j.issn.2095-6134.2018.04.009

中国科学院大学学报 ›› 2018, Vol. 35 ›› Issue (4): 481-486.DOI: 10.7523/j.issn.2095-6134.2018.04.009

超支化聚缩水甘油醚负载盐酸阿霉素纳米粒子的性能

法孟梅, 刘旭, 王蔼廉, 张辽云, 姚鑫

中国科学院大学化学科学学院, 北京 100049

收稿日期:2017-02-14 修回日期:2017-04-21 发布日期:2018-07-15
通讯作者: 姚鑫
基金资助:
天然药物及仿生药物国家重点实验室开放基金（20120207）、国家自然科学基金（21271184）、973项目（2014CB931900）和中国科学院"战略优先研究项目"（XDA09030301）资助

Performance of doxorubicin-loaded hyperbranched polyglycerol nanoparticles

FA Mengmei, LIU Xu, WANG Ailian, ZHANG Liaoyun, YAO Xin

School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2017-02-14 Revised:2017-04-21 Published:2018-07-15

摘要/Abstract

摘要： 以缩水甘油为单体，采用阴离子聚合法一步合成分子量为5 000的超支化聚缩水甘油醚（HPG），将其作为药物载体负载盐酸阿霉素（DOX）。向载体中投入不同量的DOX，用扫描电子显微镜对载药纳米粒子进行表征，用荧光标准曲线测定法研究HPG对DOX的负载及释放性能。结果表明：HPG对DOX有较好的负载性能，载药量可达到7.25%，且具有一定的缓释性和靶向释放性，药物释放时间可持续20 h以上。用HPG作为药物载体具有很大的优势，为药物载体的应用提供了很好的依据。

关键词: 超支化聚缩水甘油醚, 药物载体, 阿霉素, 负载及释放, 纳米粒子

Abstract: Hyperbranched polyglycerol (HPG) with the molecular weight of 5 000 was synthesized from the glycide monomer via anionic polymerization. HPG nanoparticles loaded with different amounts of doxorubicin (DOX) were evaluated by fluorescence and scanning electron microscope. The results showed that HPG had good loading ability for DOX. The drug loading capacity reaches 7.25%. The doxorubicin-loaded HPG nanoparticle also showed slow-releasing and target-releasing behavior. The sustained release was kept on over 20 h. All these properties of HPG nanoparticle suggest its promising potential as an effective controlled anticancer drug-delivery system.

Key words: hyperbranched polyglycerol (HPG), drug delivery, doxorubicin(DOX), loading and releasing, nanoparticles

中图分类号:

O657

法孟梅, 刘旭, 王蔼廉, 张辽云, 姚鑫. 超支化聚缩水甘油醚负载盐酸阿霉素纳米粒子的性能[J]. 中国科学院大学学报, 2018, 35(4): 481-486.

FA Mengmei, LIU Xu, WANG Ailian, ZHANG Liaoyun, YAO Xin. Performance of doxorubicin-loaded hyperbranched polyglycerol nanoparticles[J]. , 2018, 35(4): 481-486.

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超支化聚缩水甘油醚负载盐酸阿霉素纳米粒子的性能

Performance of doxorubicin-loaded hyperbranched polyglycerol nanoparticles

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