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中国科学院大学学报 ›› 2015, Vol. 32 ›› Issue (1): 51-56.DOI: 10.7523/j.issn.2095-6134.2015.01.009

• 化学与生命科学 • 上一篇    下一篇

环糊精固载量不同的壳聚糖药物载体合成及性能

秦飞, 姚鑫   

  1. 中国科学院大学化学与化工学院, 北京 100049
  • 收稿日期:2014-03-07 修回日期:2014-03-25 发布日期:2015-01-15
  • 通讯作者: 姚鑫
  • 基金资助:

    天然药物及仿生药物国家重点实验室开放基金(20120207)、国家自然科学基金(21271184)和973项目(2014CB93190,2012CB932504)资助

Preparation and drug loading performance of glycol chitosan crosslinked-carboxymethyl-beta-cyclodextrin polymers

QIN Fei, YAO Xin   

  1. School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2014-03-07 Revised:2014-03-25 Published:2015-01-15

摘要:

以乙二醇壳聚糖(GCS)为母体,通过控制交联反应条件,合成固载不同数量羧甲基β环糊精(CMβ-CD)的壳聚糖-环糊精结合物(GCSn-CMβ-CD).用核磁共振、浓硫酸-苯酚降解法等对结合物进行表征.以5-氟尿嘧啶为模型药物,用表面等离子体激元共振仪在线检测不同结合物与药物的作用.结果表明,不同结合物对药物的运载能力随环糊精数量的增加而增强,对药物的吸附规律符合Langmuir等温方程.为GCSn-CMβ-CD作为药物载体的进一步应用提供了依据.

关键词: 乙二醇壳聚糖固载羧甲基&beta, 环糊精, 药物载体, 5-氟尿嘧啶, 表面等离子体激元共振仪

Abstract:

Carboxymethyl-β-cyclodextrin (CMβ-CD) modified glycol chitosan (GCS) polymers (GCSn-CMβ-CD) were synthesized in the presence of CMβ-CD and GCS. The degree of substitution of CMβ-CD was controllable. The products were characterized by MALDI-TOF MS, 1H nuclear magnetic resonance spectrum (1H-NMR), Fourier transform infrared spectrum (FT-IR), and H2SO4-pheno degradation method. 5-fluorouracil was used as a model drug to explore the interaction with GCSn-CMβ-CD. The results indicate that different GCSn-CMβ-CD polymers showed different drug loading capacities and the adsorption equilibrium was fitted to Langmuir equation. This study provides the basis for usage of GCSn-CMβ-CD as drug carrier.

Key words: glycol chitosan crosslinked-carboxymethyl-beta-cyclodextrin, drug carrier, 5-fluorouracil, surface plasmon resonan

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