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中国科学院大学学报 ›› 2005, Vol. 22 ›› Issue (4): 467-471.DOI: 10.7523/j.issn.2095-6134.2005.4.011

• 论文 • 上一篇    下一篇

吗啡、食物诱导的条件性位置偏爱获得与保持的比较

李勇辉1,2, 郑希耕1, 鞠平1,2, 刘杰1,2, 杨晓燕1, 隋南1   

  1. 1. 中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京 100101;
    2. 中国科学院研究生院, 北京 100049
  • 收稿日期:2004-06-09 修回日期:2004-08-06 发布日期:2005-07-15
  • 通讯作者: 隋南,通讯联系人,E-mail:Suin@psych.ac.cn
  • 基金资助:

    国家重点基础研究发展计划 (973计划,2003CB515404);国家自然科学基金重点项目(30230130);中国科学院知识创新工程项目 (KSCX2SW20402)资助

Comparison between Acquisition and Retention of Morphine and Food-Induced Conditioned Place Preference

LI Yong-Hui1,2, ZHENG Xi-Geng1, JU Ping1,2, LIU Jie1,2, YANG Xiao-Yan1, SUI Nan1   

  1. 1. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
  • Received:2004-06-09 Revised:2004-08-06 Published:2005-07-15

摘要:

应用条件性位置偏爱模型研究了大鼠吗啡与食物条件性位置偏爱(CPP)获得与保持的差异,结果发现,经过6轮训练后吗啡与食物都形成相同程度的条件性位置偏爱;但5次熄灭测试后吗啡的条件性位置偏爱程度没有明显的消退,而食物的条件性位置偏爱明显消退.表明经过充分训练后吗啡与食物奖赏记忆的获得没有显著差异,但吗啡奖赏记忆保持时间更长.成瘾药物所产生的奖赏记忆的长久性可能是成瘾长期性的重要原因之一

关键词: 吗啡, 食物, 条件性位置偏爱, 获得, 记忆保持

Abstract:

To confirm the hypothesis that persistence of addiction is caused by reward-related memory of addictive drugs. 24 rats, in food restriction, were trained in biased condit ioned place preference procedure. Both morphine and food established condit ioned place preference at the same level after 6 sessions training. Food-induced CPP was extinct, while morphine- induced CPP was preserved after 4 retests. It is suggested acquisition of conditioned place preference produced by morphine and food is similar, however, morphine CPP is maintained longer. The inveterate reward-related memory induced by addictive drugs is a major factor for the persistence of addiction.

Key words: morphine, food, conditioned place preference, acquisition, retention

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