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中国科学院大学学报 ›› 2012, Vol. 29 ›› Issue (4): 571-575.DOI: 10.7523/j.issn.2095-6134.2012.4.021

• 简报 • 上一篇    

缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究

黄碧玉1,2, 吴海臣2, 杨镜奎1   

  1. 1. 中国科学院研究生院化学与化学工程学院, 北京 100049;
    2. 中国科学院高能物理研究所, 北京 100049
  • 收稿日期:2011-05-06 修回日期:2011-05-12 发布日期:2012-07-15
  • 通讯作者: 吴海臣, 杨镜奎
  • 基金资助:
    Supported by the Project of the National Natural Science Foundation of China(20972159) and the President Fund of GUCAS

Mechanistic study on hydrogenation of electron-rich substrates with electron-deficient Rh-BINAP catalyst

HUANG Bi-Yu1,2, WU Hai-Chen2, YANG Jing-Kui1   

  1. 1. College of Chemistry and Chemical Engineering, Graduate University, Chinese Academy of Sciences, Beijing 100049, China;
    2. Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
  • Received:2011-05-06 Revised:2011-05-12 Published:2012-07-15

摘要: 合成了4种富电性的脱氢α-氨基酸衍生物,将缺电子催化剂Rh-3,5-CF3-(R)-BINAP用于这几种底物的不对称氢化反应中. 讨论了底物上取代基及空间位阻对对映选择性的影响.

关键词: 富电性底物, 缺电子催化剂, 不对称氢化, 机理

Abstract: Four electron-rich α-acetamidocinnamic acid derivatives were prepared and used as substrates in the asymmetric hydrogenation catalyzed by electron-deficient Rh-3,5-CF3-(R)-BINAP. Influence of the electronic properties of substituted groups in the substrates and their steric hindrance on the enantioselectivity of the product were discussed.

Key words: electron-rich substrates, electron-deficient Rh-BINAP catalyst, asymmetric hydrogenation, mechanism

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