Relationship between angiotensin-converting enzyme gene polymorphism and hypertension disease complicated with brain infarction

doi:10.7523/j.issn.2095-6134.2010.6.007

Abstract

Abstract:

The angiotensin-converting enzyme (ACE) gene I/D polymorphism was detected in 82 cases of brain infarction (BI), 67 cases of simple essential hypertension (EH), and 95 normal cases (control). The relationship between the gene polymorphism and the hypertension disease complicated with brain infarction was evaluated. The frequencies of ACE D/D genotype and D allele (0.341 and 0.524) in the BI group were significantly higher than those in the control group (0.200 and 0.374, P<0.05) and EH group (0.179 and 0.358, P<0.05). The results suggest that ACE-DD variant may be significantly relevant to Chinese hypertensive patients with brain infarction.

Key words: angiotensin-converting enzyme, gene polymorphism, hypertension disease, brain infarction

CLC Number:

R743

DU Ming-Yan, FENG Jing, ZHOU Ju, DING Wen-Jun. Relationship between angiotensin-converting enzyme gene polymorphism and hypertension disease complicated with brain infarction[J]. , 2010, 27(6): 778-781.

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