Identification and functional study of tumor suppressor Caliban interacting proteins

doi:10.7523/j.issn.2095-6134.2011.4.009

Abstract

Abstract:

Caliban is a tumor suppressor. To understand its inherent mechanisms, we screened Caliban interacting proteins using the yeast two-hybrid system. We found four new Caliban interacting proteins, Bip2, Uba2, RpS27A, and CG7182. Moreover, over-expression of transcriptional factor Bip2 suppresses transcription of p 53. The tumor suppression function of p53 could be regulated through new mechanisms involving Bip2 and Caliban.

Key words: tumor suppressor, Caliban, yeast two hybrid, Bip2

CLC Number:

WANG Zhe, ZHANG Jie, ZHAO Yu-Liang, BI Xiao-Lin. Identification and functional study of tumor suppressor Caliban interacting proteins[J]. , 2011, 28(4): 481-488.

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