Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction

doi:10.7523/j.issn.2095-6134.2010.1.017

Abstract

Abstract:

The angiotensinogen (AGT) gene polymorphism was detected in the study of 82 cerebral infraction (BI) cases, 67 simple essential hypertension (EH) cases, and 95 normal cases (control) using mutagenically separated PCR (MS-PCR) technique. The association of the AGT gene CD235Met-Thr variant and cerebral infraction (BI) in Chinese hypertension disease is evaluated. The frequencies of T/T genotype and T allele (0.720 and 0.811) in the BI group were significantly higher than those in the control group (0.516 and 0.700, P<0.05) and the EH group (0.537 and 0.716, P<0.05), respectively. These results suggest that the AGT gene CD235Met-Thr variant is significantly associated with Chinese hypertensive patients with cerebral infraction.

Key words: angiotensinogen, MS-PCR, hypertension disease, cerebral infraction

CLC Number:

R743

DU Ming-Yan, DU Hui-Shan, ZHOU Ju, DING Wen-Jun. Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction[J]. , 2010, 27(1): 133-137.

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