Effect of autophagy on hepatic lipid metabolism in liver

doi:10.7523/j.issn.2095-6134.2016.04.020

Abstract

Abstract:

It has been well demonstrated that lipid accumulation in liver of the obesity is involved in endoplasmic reticulum stress, mitochondria dysfunction, and lipotoxicity, which is associated with insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD).Autophagy has been considered to be an adaptive response to stress, contributing to cellular homeostasis.It has been found that autophagy is activated during hepatic lipid accumulation.Autophagy plays an essential role in maintaining hepatic lipid metabolism.This review summarizes recent studies to identify the molecular mechanism of autophagy maintaining hepatic lipid metabolism in the obesity.

Key words: obesity, liver, autophagy, lipid metabolism

CLC Number:

R575.5

HUANG Ying, ZHANG Fang, DING Wenjun. Effect of autophagy on hepatic lipid metabolism in liver[J]. , 2016, 33(4): 570-575.

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