Journal of University of Chinese Academy of Sciences >
Prediction of Configuration for the Colchicine onthe Basis of the Helix Theory
Received date: 2003-01-20
Revised date: 2003-06-13
Online published: 2004-03-19
The colchicine is an important medicine for cancer.There are not only configurational problems of chiralcarbon atom but the problems of configuration and conformation similar to the biphenyl derivatives.The configurationand conformation between the two aromatic rings need to be determined after the configuartion of chiral carbon atomis determined.According to the helix theory proposed by the authors,the configuration and conformation between thetwo aromatic rings of colchicine can be conveniently deduced from its rotatory direction and value of rotation.
Key words： colchicine; configuration; helix theory
YIN Yu-Ying , LIU Chun-Yun . Prediction of Configuration for the Colchicine onthe Basis of the Helix Theory[J]. Journal of University of Chinese Academy of Sciences, 2004 , 21(2) : 164 -167 . DOI: 10.7523/j.issn.2095-6134.2004.2.003
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