Prediction of Configuration for the Colchicine onthe Basis of the Helix Theory

doi:10.7523/j.issn.2095-6134.2004.2.003

›› 2004, Vol. 21 ›› Issue (2): 164-167.DOI: 10.7523/j.issn.2095-6134.2004.2.003

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Prediction of Configuration for the Colchicine onthe Basis of the Helix Theory

YIN Yu-Ying, LIU Chun-Yun

Beijing Institute of Petrochemical Technology, Beijing 102600, China

Received:2003-01-20 Revised:2003-06-13 Online:2004-03-19

Abstract

Abstract:

The colchicine is an important medicine for cancer.There are not only configurational problems of chiralcarbon atom but the problems of configuration and conformation similar to the biphenyl derivatives.The configurationand conformation between the two aromatic rings need to be determined after the configuartion of chiral carbon atomis determined.According to the helix theory proposed by the authors,the configuration and conformation between thetwo aromatic rings of colchicine can be conveniently deduced from its rotatory direction and value of rotation.

Key words: colchicine, configuration, helix theory

CLC Number:

O621.13

YIN Yu-Ying, LIU Chun-Yun. Prediction of Configuration for the Colchicine onthe Basis of the Helix Theory[J]. , 2004, 21(2): 164-167.

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Prediction of Configuration for the Colchicine onthe Basis of the Helix Theory

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