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Effectofvanadiumonbloodglucoselevels:acomparisonstudyinmaleand femaleKKmicewithgeneticnoninsulindependentdiabetes mellit-us

  • ZHOUJu ,
  • PENGDuan ,
  • LIMing ,
  • DINGWen Jun
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  • CollegeofLifeSciences,GraduatesUniversityofChineseAcademyofSciences,Beijing100049,China

Received date: 1900-01-01

  Revised date: 1900-01-01

  Online published: 2008-03-15

Abstract

Theeffectoforaladministrationofvanadium(V)onbloodglucosewasexaminedinthemaleandfemale KKmicewithgeneticnoninsulindependentdiabetesmellitus(NIDDM).Themajordifferencesbetweenmalesand femaleswereobservedintheirsensitivitytohighconcentrationofvanadium(100mg?L)throughdrinkingwater.The
resultsobtainedfrommalemiceshowedthatwaterintake,bloodglucoseandhemoglobinA1c(HbA1c)levels,triglyceride(TG),highdensitylipoproteincholesterol(HDLc),andtotalcholesterol(TCHO)weresignificantlydecreasedwithoutanyeffectonbodyweight.Furthermore,theplasma1,5anhydroglucitol(1,5AG)concentrationandglucosetoleranceweresignificantlyincreasedandimprovedafter100mg?Lofvanadiumtreatment.Inaddition,vanadiumhadnoeffectonplasmaglutamicpyruvictransaminase(GPT)andglutamicoxaloacetatetransaminase(GOT)activities,andbloodureanitrogen(BUN)levelsascomparedwiththecontrols.Theseresultssuggestthat therearesignificantsexdifferencesinsensitivitytovanadiumwithaglucoseloweringdoseinmaleandfemaleKK
mouse.Theglucoseloweringeffectsweremoremarkedinmalesthaninfemales.

Cite this article

ZHOUJu , PENGDuan , LIMing , DINGWen Jun . Effectofvanadiumonbloodglucoselevels:acomparisonstudyinmaleand femaleKKmicewithgeneticnoninsulindependentdiabetes mellit-us[J]. Journal of University of Chinese Academy of Sciences, 2008 , 25(2) : 192 -196 . DOI: 10.7523/j.issn.2095-6134.2008.2.008

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