Journal of University of Chinese Academy of Sciences >
Relationship between angiotensin-converting enzyme gene polymorphism and hypertension disease complicated with brain infarction
Received date: 2010-05-28
Online published: 2010-11-15
The angiotensin-converting enzyme (ACE) gene I/D polymorphism was detected in 82 cases of brain infarction (BI), 67 cases of simple essential hypertension (EH), and 95 normal cases (control). The relationship between the gene polymorphism and the hypertension disease complicated with brain infarction was evaluated. The frequencies of ACE D/D genotype and D allele (0.341 and 0.524) in the BI group were significantly higher than those in the control group (0.200 and 0.374, P<0.05) and EH group (0.179 and 0.358, P<0.05). The results suggest that ACE-DD variant may be significantly relevant to Chinese hypertensive patients with brain infarction.
DU Ming-Yan , FENG Jing , ZHOU Ju , DING Wen-Jun . Relationship between angiotensin-converting enzyme gene polymorphism and hypertension disease complicated with brain infarction[J]. Journal of University of Chinese Academy of Sciences, 2010 , 27(6) : 778 -781 . DOI: 10.7523/j.issn.2095-6134.2010.6.007
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