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Optimization of Reaction Conditions in the Asymmetric Synthesis of D-Mandelic Acid Methyl Ester Catalyzed by Saccharomyces Cereviriae
Received date: 2004-06-09
Revised date: 2004-08-16
Online published: 2005-03-15
In the process of asymmetric synthesis of D-mandelic acid methyl ester catalyzed by Saccharomyces cereviriae, the most favorite pH for conversion is 7.0.Both the environmental temperature and oxygen concentration all have an important effect on conversion of substrate.Using packed bed reactor filled with immobilized cells to produce D-mandelic acidmethyl ester,25 days later the conversion efficiency can be still sustained in 80 %and the ee value is more than 95 %when the charge was 0.2 mmol (d·g)wet cell.
SHENG Jun , GUO Yang-Hao , SHI Xian-Ai , XIAO Mei-Tian , MENG Chun . Optimization of Reaction Conditions in the Asymmetric Synthesis of D-Mandelic Acid Methyl Ester Catalyzed by Saccharomyces Cereviriae[J]. Journal of University of Chinese Academy of Sciences, 2005 , 22(2) : 192 -196 . DOI: 10.7523/j.issn.2095-6134.2005.2.011
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