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Protective effect of a new formula based on nitric oxide and natural antioxidants on myocardium

  • FENG Run ,
  • WANG Hongyun ,
  • ZHAO Baolu ,
  • LU Zhongbing
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  • 1 College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China;
    2 Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Received date: 2015-12-02

  Revised date: 2016-03-09

  Online published: 2016-09-15

Abstract

ZPF1 is a new formula that is composed of L-Arg and several natural antioxidants. In this study, the cardioprotective effect of ZPF1 has been investigated. It was found that ZPF1 promotes H9C2 cell growth and decreases intracellular ROS level in phenylephrine-treated cells. ZPF1 also attenuates isoprenaline-induced cardiac hypertrophy and dysfunction in mice, which is due to SERCA2a up-regulation.Our findings suggest that the combination of NO and natural antioxidants serves possible therapeutic intervention against heart failure.

Cite this article

FENG Run , WANG Hongyun , ZHAO Baolu , LU Zhongbing . Protective effect of a new formula based on nitric oxide and natural antioxidants on myocardium[J]. Journal of University of Chinese Academy of Sciences, 2016 , 33(5) : 625 -631 . DOI: 10.7523/j.issn.2095-6134.2016.05.008

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