Protective effect of a new formula based on nitric oxide and natural antioxidants on myocardium

doi:10.7523/j.issn.2095-6134.2016.05.008

Abstract

Abstract:

ZPF1 is a new formula that is composed of L-Arg and several natural antioxidants. In this study, the cardioprotective effect of ZPF1 has been investigated. It was found that ZPF1 promotes H9C2 cell growth and decreases intracellular ROS level in phenylephrine-treated cells. ZPF1 also attenuates isoprenaline-induced cardiac hypertrophy and dysfunction in mice, which is due to SERCA2a up-regulation.Our findings suggest that the combination of NO and natural antioxidants serves possible therapeutic intervention against heart failure.

Key words: nitric oxide (NO), natural antioxidants, myocardial hypertrophy

CLC Number:

R285.5

FENG Run, WANG Hongyun, ZHAO Baolu, LU Zhongbing. Protective effect of a new formula based on nitric oxide and natural antioxidants on myocardium[J]. , 2016, 33(5): 625-631.

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