Journal of University of Chinese Academy of Sciences >
Computer Simulation of Tb( Ⅲ )Speciation in Human Blood Plasma
Received date: 2002-01-04
Online published: 2003-01-18
Supported by
supported by National Natural Acience Found at ionof China(29890280;29971029)
A multi-phase model of human blood plasma was developed and the Tb( Ⅲ) specia-tion in this system was studied. The results show that the speciation of Tb( Ⅲ ) depends onthe concentration of Tb( Ⅲ ). When the concentration of Tb( Ⅲ ) is below 4. 000 × 10-8 mol/L,most of Tb ( Ⅲ ) exists as soluble species while the concentration of Tb ( Ⅲ ) is in between4. 000× 10-8 mol/L and 1. 667 × 10-2 mol/L, precipitates (TbPO4 and Tb2 (CO3)3) are thedominant species of Tb(Ⅲ). Among soluble Tb(Ⅲ) species, Tb( Ⅲ) is mostly bound to thetransferrin to form [Tb(Tf)] when the concentration of soluble Tb(Ⅲ) is below 1.0 × 10-4mol/L. The concentration of soluble Tb(Ⅲ) reaches 1.0 × 10-4mol/L, thus available trans-ferrin is exceeded, and soluble Tb(Ⅲ) ions mainly distribute in [Tb(HSA)], [Tb2 (Tf)],[Tb(Ox)] and [Tb(Cit)] etc.
Key words： computer simulation; speciation; human blood plasma; terbium( Ⅲ)
Lu Xing , Zhang Haiyuan , Wang Jinping , Wang Yue , Yang Kuiyue , Niu Chunji , Ni Jiazuan . Computer Simulation of Tb( Ⅲ )Speciation in Human Blood Plasma[J]. Journal of University of Chinese Academy of Sciences, 2003 , 20(1) : 7 -12 . DOI: 10.7523/j.issn.2095-6134.2003.1.002
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