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›› 2003, Vol. 20 ›› Issue (1): 7-12.DOI: 10.7523/j.issn.2095-6134.2003.1.002

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Computer Simulation of Tb( Ⅲ )Speciation in Human Blood Plasma

Lu Xing, Zhang Haiyuan, Wang Jinping, Wang Yue, Yang Kuiyue, Niu Chunji, Ni Jiazuan   

  1. Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2002-01-04 Online:2003-01-18
  • Supported by:

    supported by National Natural Acience Found at ionof China(29890280;29971029)

Abstract:

A multi-phase model of human blood plasma was developed and the Tb( Ⅲ) specia-tion in this system was studied. The results show that the speciation of Tb( Ⅲ ) depends onthe concentration of Tb( Ⅲ ). When the concentration of Tb( Ⅲ ) is below 4. 000 × 10-8 mol/L,most of Tb ( Ⅲ ) exists as soluble species while the concentration of Tb ( Ⅲ ) is in between4. 000× 10-8 mol/L and 1. 667 × 10-2 mol/L, precipitates (TbPO4 and Tb2 (CO3)3) are thedominant species of Tb(Ⅲ). Among soluble Tb(Ⅲ) species, Tb( Ⅲ) is mostly bound to thetransferrin to form [Tb(Tf)] when the concentration of soluble Tb(Ⅲ) is below 1.0 × 10-4mol/L. The concentration of soluble Tb(Ⅲ) reaches 1.0 × 10-4mol/L, thus available trans-ferrin is exceeded, and soluble Tb(Ⅲ) ions mainly distribute in [Tb(HSA)], [Tb2 (Tf)],[Tb(Ox)] and [Tb(Cit)] etc.

Key words: computer simulation, speciation, human blood plasma, terbium( Ⅲ)

CLC Number: