Glycol chitosan-graft-carboxymethyl β-cyclodextrin as carrier of hydrophobic anticancer drug methotrexate

doi:10.7523/j.issn.1002-1175.2013.02.009

Abstract

Abstract:

Glycol chitosan-graft-carboxymethyl β-cyclodextrin (GCH-g-CM β-CD) was synthesized by a simple cross-linking reaction, and the products were characterized by FT-IR,¹³C-NMR, and H₂SO₄-phenol degradation method. Interaction between GCH-g-CM β-CD and hydrophobic anticancer drug methotrexate (MTX) was studied by surface plasmon resonance (SPR) in real time and in situ. UV-vis spectroscopy analysis indicated that each CM β-CD unit binds one MTX molecule, which showed that MTX can be successfully loaded into the hydrophobic cavities of grafted CM β-CDs. The results indicated that the newly synthesized GCH-g-CM β-CD can be used as hydrophobic anticancer drug carrier.

Key words: glycol chitosan-graft-carboxymethyl β-cyclodextrin, drug carrier, anticancer drug, methotrexate, surface plasmon resonance

CLC Number:

O657

TAN Hai-Na, YAO Xin. Glycol chitosan-graft-carboxymethyl β-cyclodextrin as carrier of hydrophobic anticancer drug methotrexate[J]. , 2013, 30(2): 200-205.

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