Preparation and drug loading performance of glycol chitosan crosslinked-carboxymethyl-beta-cyclodextrin polymers

doi:10.7523/j.issn.2095-6134.2015.01.009

Abstract

Abstract:

Carboxymethyl-β-cyclodextrin (CMβ-CD) modified glycol chitosan (GCS) polymers (GCS_n-CMβ-CD) were synthesized in the presence of CMβ-CD and GCS. The degree of substitution of CMβ-CD was controllable. The products were characterized by MALDI-TOF MS, ¹H nuclear magnetic resonance spectrum (¹H-NMR), Fourier transform infrared spectrum (FT-IR), and H₂SO₄-pheno degradation method. 5-fluorouracil was used as a model drug to explore the interaction with GCS_n-CMβ-CD. The results indicate that different GCS_n-CMβ-CD polymers showed different drug loading capacities and the adsorption equilibrium was fitted to Langmuir equation. This study provides the basis for usage of GCS_n-CMβ-CD as drug carrier.

Key words: glycol chitosan crosslinked-carboxymethyl-beta-cyclodextrin, drug carrier, 5-fluorouracil, surface plasmon resonan

CLC Number:

O657

QIN Fei, YAO Xin. Preparation and drug loading performance of glycol chitosan crosslinked-carboxymethyl-beta-cyclodextrin polymers[J]. , 2015, 32(1): 51-56.

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