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›› 2002, Vol. 19 ›› Issue (4): 388-393.DOI: 10.7523/j.issn.2095-6134.2002.4.009

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Computer Simulation for Effect of Pr(Ⅲ)on Zn(Ⅱ)Speciation in Human Interstitial Fluid

ZHANG Hai Yuan1, WANG Jin Ping1, LU Xin1, g NIU Chun Ji1, NI Jia Zuan1   

  1. Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022
  • Received:2002-01-21 Revised:2002-04-08 Online:2002-07-18

Abstract:

A muti-phase model of metal ion speciation in human interstitial fluid has been const ructed and the effect of Pr(Ⅲ)on Zn(Ⅱ)speciation has also been studied.Result s show that Pr (Ⅲ)ions influence the distribution of Zn (Ⅱ)species.Zn (Ⅱ)is mainly dist ributed as [ Zn (HSA)], [ Zn(IgG)] and [ Zn(Cys)2H].Pr(Ⅲ)can not compete wi th Zn(Ⅱ)to fo rm HSA and IgG complex, w hile it can compete w ith Zn(Ⅱ)as phosphate and carbonate, causing the redist ribution of Zn(Ⅱ)species.

Key words: computer simulation, effect, speciation, human interstitial fluid

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