Effects of anti-hepatitis B virus drugs on sperm quality of patients with chronic hepatitis B

doi:10.7523/j.issn.2095-6134.2014.04.003

Abstract

Abstract:

The aim of this study was to investigate the effects of interferon, lamivudine, and adefovir on sperm quality in patients with chronic hepatitis B. A total of 90 patients with HBeAg-positive chronic hepatitis B were randomly divided into interferon-treated group, lamivudine-treated group, and adefovir-treated group. HBsAg, HBeAg, and Anti-HBe serum conversion rates, serum HBV-DNA, and alanine aminotransferase (ALT) levels in serum were measured. In addition the density and motility of sperm in these patients were also measured 6 months ofter drug with drawal. The results show that the density and motility of sperm significantly decreased in all the groups (P<0.05;P<0.01). This impairment on sperm quality was improved 6 months after drug withdrawal. The results suggest that the adverse effects of anti-hepatitis B drugs on sperm quality in chronic hepatitis B patients at reproductive age should be considered.

Key words: chronic hepatitis B, interferon, lamivudine, adefovir, sperm quality

CLC Number:

R512.6

SONG Dan, LI Lingwei, TIAN Jingyan, GAN Feifei, WANG Jian, HAN Rui, ZHANG Fang. Effects of anti-hepatitis B virus drugs on sperm quality of patients with chronic hepatitis B[J]. , 2014, 31(4): 460-465.

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