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›› 2008, Vol. 25 ›› Issue (2): 192-196.DOI: 10.7523/j.issn.2095-6134.2008.2.008

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Effectofvanadiumonbloodglucoselevels:acomparisonstudyinmaleand femaleKKmicewithgeneticnoninsulindependentdiabetes mellit-us

ZHOUJu PENGDuan LIMing DINGWenJun   

  1. CollegeofLifeSciences,GraduatesUniversityofChineseAcademyofSciences,Beijing100049,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-03-15

Abstract: Theeffectoforaladministrationofvanadium(V)onbloodglucosewasexaminedinthemaleandfemale KKmicewithgeneticnoninsulindependentdiabetesmellitus(NIDDM).Themajordifferencesbetweenmalesand femaleswereobservedintheirsensitivitytohighconcentrationofvanadium(100mg?L)throughdrinkingwater.The
resultsobtainedfrommalemiceshowedthatwaterintake,bloodglucoseandhemoglobinA1c(HbA1c)levels,triglyceride(TG),highdensitylipoproteincholesterol(HDLc),andtotalcholesterol(TCHO)weresignificantlydecreasedwithoutanyeffectonbodyweight.Furthermore,theplasma1,5anhydroglucitol(1,5AG)concentrationandglucosetoleranceweresignificantlyincreasedandimprovedafter100mg?Lofvanadiumtreatment.Inaddition,vanadiumhadnoeffectonplasmaglutamicpyruvictransaminase(GPT)andglutamicoxaloacetatetransaminase(GOT)activities,andbloodureanitrogen(BUN)levelsascomparedwiththecontrols.Theseresultssuggestthat therearesignificantsexdifferencesinsensitivitytovanadiumwithaglucoseloweringdoseinmaleandfemaleKK
mouse.Theglucoseloweringeffectsweremoremarkedinmalesthaninfemales.

Key words: vanadium, KKmouse, bloodglucose, metabolismoflipidandcholesterol, sexdifference

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