Comparative study of cytotoxicity of winter and summer PM10 and PM2.5 in A549 cells

doi:10.7523/j.issn.2095-6134.2012.3.007

Abstract

Abstract: Effects of winter and summer PM₁₀ and PM_2.5 collected at Beijing on the cell viability and reactive oxygen species (ROS) generation in human lung epithelia cells (A549) were investigated. We have found that cytotoxicity of summer PM is higher than that of winter PM. Transition metal elements, except Cr and Ni, have positive associations with toxic effects in A549 cells. These results suggest that transition metals in particulate matter (PM) may have the toxic effects in vitro.

Key words: particulate matters, cytotoxicity, oxidative stress, transition metals, seasonal variations

CLC Number:

HE Qing, DING Wen-Jun, RUI Wei, ZHANG Fang. Comparative study of cytotoxicity of winter and summer PM₁₀ and PM_2.5 in A549 cells[J]. , 2012, (3): 324-331.

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Comparative study of cytotoxicity of winter and summer PM₁₀ and PM_2.5 in A549 cells

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