Effect of vanadium(V)-chlorodipicolinate on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice

doi:10.7523/j.issn.2095-6134.2013.05.007

Abstract

Abstract: The insulin-mimic effect of vanadium compounds has been reported in both type Ⅰ and Ⅱ diabetic animal models, but the effect of vanadium compounds on lipid metabolism remains to be fully understood. We investigate the effect of V₅dipic-Cl on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice. V₅dipic-Cl was administered daily to the mice for 28 days at dose of 5 mg/(kg·d) by oral gavages. It was found that the blood glucose level and serum TG were significantly reduced after treatment with V₅dipic-Cl. It is suggested that V₅dipic-Cl improves the lipid metabolism by promoting fatty acid oxidation in liver.

Key words: V₅dipic-Cl, type Ⅱ diabetes, metabolic disorder, C57BL/6J, fatty acid oxidation

CLC Number:

Q591.5

ZHANG Wei, CHEN De-Liang, ZHANG Fang, LIU Yang, DING Wen-Jun. Effect of vanadium(V)-chlorodipicolinate on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice[J]. , 2013, 30(5): 613-619.

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